Process for adsorbing and removing tumor necrosis factor-.alpha.

Details Process for adsorbing and removing tumor necrosis factor-.alpha. Process for adsorbing and removing tumor necrosis factor-.alpha.

1999-04-02

2000-10-03

Borin, Michael

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

530351, 530412, 530417, 930144, C07K 122, C07K 114, C07K 1400, A61K 3819

Patent

active

06127528&

ABSTRACT:
The present invention relates to an adsorbent being capable of efficiently removing tumor necrosis factor-.alpha. (TNF-.alpha.) in a body fluid, an adsorber using the adsorbent and a process for adsorbing and removing TNF-.alpha., namely an adsorbent of TNF-.alpha., wherein onto a water-insoluble carrier a compound having a functional group represented by the formula (I): ##STR1## wherein X.sup.- is an anionic functional group, A is a substituent group except for the anionic functional group, n is an integer of 0 to 4 and in case n is at least 2, groups A, the number of which is n, may be the same or different from each other; a process for adsorbing and removing TNF-.alpha., which comprises coming the adsorbent into contact with a body fluid; and an adsorber for adsorbing TNF-.alpha. wherein a vessel having an inlet and an outlet for a body fluid and being equipped with a means for preventing the adsorbent from flowing to the outside of the vessel, is charged with the adsorbent.

REFERENCES:
patent: 4997874 (1991-03-01), Asano et al.
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patent: 5679775 (1997-10-01), Boos et al.
Database CAPLUS, AN: 1985:543086, JP 60088041, May 17, 1985.
Database CAPLUS, AN: 1968:478047; Zundel, G. Kunstst. Rundsch., 15(4), 166-71.
Database CAPLUS, AN: 1992:175620; J. Membr. Sci., 64(3), 255-62.
Database CAPLUS, AN:2755; JP 58124798.

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