Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2005-07-26
2010-06-15
Berch, Mark L (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
active
07737273
ABSTRACT:
The present invention provides a novel process for the preparation of acyclic phosphonate nucleotide analogs using novel intermediates. Thus, for example, (R)-9-(2-phosphonomethoxypropyl)adenine is reacted with dimethylformamide dimethylacetal to give N4-dimethylaminomethyledino-9-(2-phosphonomethoxy ethyl) adenine, which is then reacted with chloromethyl-2-propyl carbonate in presence of triethylamine to give (R)-N4-Dimethylaminomethyledino-9-(2-phosphono methoxypropyl) adenine disoproxil, followed by deprotection with acetic acid to get tenofovir disoproxil. Tenofovir disoproxil is then treated with fumaric acid to give tenofovir disoproxil fumarate.
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PCT Notification of Transmittal of the International Search Reort and the Written Opinion of the International Search Authority, International Application No. PCT/IN2005/000247.
Muralidhara Reddy Dasari
Parthasaradhi Reddy Bandi
Raji Reddy Rapolu
Rathnakar Reddy Kura
Berch Mark L
Caesar Rivise Bernstein Cohen & Pokotilow Ltd.
Hetero Drugs Limited
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