Process for activation of drugs in a vibrational mill

Details Process for activation of drugs in a vibrational mill Process for activation of drugs in a vibrational mill

2011-05-31

2011-05-31

Wax, Robert A (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

C241S026000, C241S027000, C241S175000

Reexamination Certificate

active

07951399

ABSTRACT:
A process is described for the activation (increase in solubility and bioavailability) of drugs. The process, carried out in a vibrational mill, is characterised by the use of given proportions between the physical mixture made up of drug and pharmaceutical carrier and the empty volume among the grinding means contained inside the mill. The process leads to obtaining powders for pharmaceutical use in which the drug has a high and constant degree of activation; this result is obtainable irrespective of the nature of the drug and carrier used, and of their weight ratio.

REFERENCES:
patent: 4932166 (1990-06-01), Boecker et al.
patent: 5626662 (1997-05-01), Urban
patent: 96/32931 (1996-10-01), None
patent: WO 96/32931 (1996-10-01), None
Nakai et al., “Effects of Grinding on Physical and Chemical Properties of Crystalline Medicinals with Microcrystalline Cellulose. I. Some Physical Properties of Crystalline Medicinals in Ground Mixtures”,Chem. Pharm. Bull., 25, pp. 3340-3346 (1977).
Kawano et al., “Physichemical Properties of Ground Mixtures of Crystalline Medicinals with Microcrystalline Cellulose or Cyclodextrins,”J. Pharm. Dyn., 5, s-4 (1982).
Sweco Manual entitled “Installation, Operation & Maintenance Specifications for DM28L Food Grace Vibro-Energy Grinding Mill for Vectorpharma Int'l. SPA” (1997).
Nogami et al., “Studies on Powdered Preparations. XVII. Dissolution Rate of Sulfomides by Rotating Disk Method”,Chem. Pharm. Bull., 14, pp. 329-338 (1966).
“Pharmaceutical Technical Procedures”,European Pharmacopoeia, pp. 141-142 (1997).

Affiliated with

Also associated with

Rating

Process for activation of drugs in a vibrational mill does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for activation of drugs in a vibrational mill, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for activation of drugs in a vibrational mill will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2703304