Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound having a 1-thia-4-aza-bicyclo
Patent
1995-02-09
1996-05-28
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound having a 1-thia-4-aza-bicyclo
435 44, 435230, 435813, C12P 3700
Patent
active
055210686
ABSTRACT:
The invention relates to an improved process for converting 6-acylaminopenicillanic acid (6-AAPA) to 6-aminopenicillanic acid (6-APA). The process employs a solution or suspension of penicillin acylase from which the product is separated after reaction by ultrafiltration through a particular class of polymer membranes. The process of the invention may also be applied to the production of 7-aminodesacetoxycephalosporanic acid (7-ADCA) and can be incorporated into an improved, streamlined process for obtaining 6-APA from fermentation broths.
REFERENCES:
patent: 3161573 (1964-12-01), Godtfredsen
patent: 3615024 (1968-08-01), Michaels
patent: 3887432 (1975-06-01), Cawthorne
patent: 4033817 (1977-07-01), Gregor
patent: 4371612 (1983-02-01), Matsumoto et al.
patent: 4664808 (1987-05-01), Kim
patent: 4800162 (1989-01-01), Matson
J. Bryjak & A. Noworyta, "Enzyme Membrane Bioreactor for Hydrolysis of Penicillin G", Biochem. Eng.--Stuttgart, [Proc. Int. Symp.], 2nd, Meeting (1990) 122-5. Edited by: Reuss, Matthias. Fischer: Stuttgart, Fed. Rep. Ger.
Giacobbe et al., "Production of 6APA in the Penicillin G Fermentation Plant by Using Fiber-Entrapped Penicillin Amidase", Enzyme Eng., 4, 245-252 (1978).
Barenschee et al. "Possibilities of Liquid Membrane Technology for Immobilisation of Enzymes" Chem. Ing. Tech. 61, 426-427 (1989).
Tiskas et al. "Hohlfasergestutzte Flussigmembranen zur Extraktion . . . " Chem. Ing. Tech. 64, 545-548 (1992).
Michaels et al. "Membranes in Biotechnology: State of the Art" Desalination 53, 231-258 (1985).
Veronese et al. "Immobilization of Purified Penicillin Acylase in a Polarized Ultrafiltration Membrane Reactor" Ann. N.Y. Acad. Sci. 434 (Enzyme Eng.) 127-130 (1984).
Ryu et al. "Microbial Penicillin Amidohydrolase and the Performance of a Continuous Enzyme Reactor System" Proc. IV IFS: Ferment. Technol. Today, 307-314 (1972).
Lilling Herbert J.
Sepracor Inc.
LandOfFree
Process for 7-aminodesacetoxycephalosporanic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for 7-aminodesacetoxycephalosporanic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for 7-aminodesacetoxycephalosporanic acid will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-785901