Process for 5'-phosphorylation of nucleic acids

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 28, 536 29, C08H 2100, C08H 2102, C08H 2104

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050397966

ABSTRACT:
Compounds of the formula ##STR1## are phosphorylating reagents which react with acylatable hydrogen atoms with elimination of the amine HNR.sup.3 R.sup.4. The resulting compounds are oxidized to give the corresponding phosphate, thiophosphate or selenophosphate derivatives, and the radicals R.sup.1 and R.sup.2 are then split off by means of bases. The chemical nature of the radicals R.sup.1, R.sup.2, R.sup.3 and R.sup.4 accordingly depends on the requirements for these cleavage reactions.

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Chemical Abstract, vol. 79, No. 53549y.
Chemical Abstract No. 101, No. 230935s.
Chemical Abstract vol. 78, No. 57700t.

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