Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5

Details Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5 Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5

1982-09-03

1984-10-16

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546203, 548528, 568323, 568326, 568808, 564151, 564300, 564308, 564310, 260349, C07D47108

Patent

active

044776683

ABSTRACT:
(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine, and its pharmaceutically acceptable salts is useful as an anxiolytic, antidepressant, anticonvulsant, muscle relaxant and in the treatment of mixed anxiety-depression, minimal brain dysfunction and extrapyramidal disorders such as Parkinson's disease. The racemate of the compound is produced by a four-step synthetic process in about 65% yield from 5H-dibenzo[a,d]cyclohepten-5-one.

REFERENCES:
patent: 3717641 (1973-02-01), Kocsis et al.
patent: 4232158 (1980-11-01), Shepard et al.
Marched, Advanced Organic Chemistry, 2nd ed., (1977), p. 836.
Christy et al., J. Org. Chem., 44, 3117-3127 (1979).
Evans et al., J. Org. Chem., 44, 3127-3135 (1979).
Evans et al., J. Org. Chem. 46, 140-143 (1981).
House et al., J. Org. Chem. 41, 855-869 (1976).

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