Process for 4a'(R),5'-dihydromevinolin

Details Process for 4a'(R),5'-dihydromevinolin Process for 4a'(R),5'-dihydromevinolin

1983-06-20

1984-12-25

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30930

Patent

active

044905467

ABSTRACT:
Mevinolin is converted to its 4a',5'-dihydro derivative by a route involving protection of the 3',4'-double bond followed by reduction of the 4a',5'-double bond followed by deprotection of the 3',4'-positions.

REFERENCES:
patent: 4282155 (1981-08-01), Smith et al.
patent: 4293496 (1981-10-01), Willard
patent: 4294846 (1981-10-01), Albers-Schonberg et al.
Albers-Schonberg et al., J. Antibiotics, 34, 507-512 (1981).
Prinzbach et al., Agnew. Chem., Int'l. Ed., 14, 753-755 (1975).
Corey et al., J. Am. Chem. Soc., 85, 2677-2678 (1963).

Affiliated with

Also associated with

Rating

Process for 4a'(R),5'-dihydromevinolin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for 4a'(R),5'-dihydromevinolin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for 4a'(R),5'-dihydromevinolin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1153879