Process for 4,6-di-substituted 2-aminopyrimidines

Details Process for 4,6-di-substituted 2-aminopyrimidines Process for 4,6-di-substituted 2-aminopyrimidines

1986-01-21

1988-02-02

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544326, 544330, 544331, 544334, C07D23947

Patent

active

047230061

ABSTRACT:
New compounds useful as intermediates for biologically-active compounds have the formula I ##STR1## wherein Y is a group having the formula --CH.sub.2 X in which X is F, Cl, or Br, or Y is a group having the formula ##STR2## in which R.sup.2 is F, Cl or Br and R.sup.3 is H, F, Cl, Br or a group having the formula --CR.sup.4 R.sup.5 R.sup.6, in which R.sup.4, R.sup.5 and R.sup.6, independently, are F, Cl or Br; A is H, OH, SH, F, Cl, Br or a group --OR.sup.7 or --SR.sup.7 in which R.sup.7 is C.sub.1 -C.sub.4 straight- or branched chain alkyl, C.sub.2-4 straight- or branched chain alkyl substituted with 1 to 3 F, Cl or Br atoms, or A is a group --NR.sup.8 R.sup.9 in which R.sup.8 and R.sup.9, independently, are H, C.sub.1 -C.sub.4 straight- or branched chain alkyl or C.sub.3 -C.sub.4 alkenyl, or R.sup.8 and R.sup.9 together may form a C.sub.3 -C.sub.7 polymethylene chain, which is optionally interrupted by an oxygen atom; as well as salts of compounds of formula I with acids; provided that: when Y is CH.sub.2 F, then A is as hereinbefore defined other than OH, Cl or OCH.sub.3.

REFERENCES:
patent: 2658895 (1953-11-01), Ballard et al.
patent: 3050523 (1962-08-01), Erner et al.
Bergmann, et al.; J. Chem. Soc., (1959), pp. 3278-3285.
Elderfield, "Heterocyclic Compounds", vol. 6, (1957), pp. 265 & 268-270,; John Wiley & Sons; N.Y.

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