Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound having a 1-thia-5-aza-bicyclo
Patent
1982-11-16
1984-10-02
Hazel, Blondel
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound having a 1-thia-5-aza-bicyclo
435117, 435177, C12P 3500
Patent
active
044748795
ABSTRACT:
This invention relates to a process for preparing 7-(S)-acylamino-3-hydroxymethyl-3-cephem-4-carboxylic acid sulfones and the salts and esters thereof. The instant process involves contacting a 7-(S)-acylamino-3-acetoxymethyl cephalosporin sulfone in an aqueous solution buffered from about pH 6 to about pH 8 with citrus acetylesterase, which is immobilized on silica gel. The 3-hydroxymethyl cephalosporin sulfones produced by the process of this invention are intermediates in the synthesis of 1-oxa .beta.-lactam antibiotics.
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Durkheimer, W., et al., "HR 109, A Highly Active Cepholosporin (S)-Sulfoxide" in Recent Advances in the Chemistry of .beta.-Lactam Antibiotics, Gregory, G. I. (Ed.), pp. 46-56, 1980.
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Eli Lilly and Company
Hazel Blondel
Huleatt Jayme A.
Steinhardt Paul C.
Whale Arthur R.
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