Process for 3-hydroxy benzodiazepinones

Details Process for 3-hydroxy benzodiazepinones Process for 3-hydroxy benzodiazepinones

1982-04-30

1983-11-01

Bond, Robert T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D24326

Patent

active

044129521

ABSTRACT:
Conversion of 3-acyloxy-benzodiazepin-2-ones into corresponding 3-hydroxy benzodiazepin-2-ones is carried out efficiently with potassium hydroxide or potassium alkoxide as catalyst in lower alkanol solvent at a pH of 11-11.5. The final products, which include temazepam, are useful as sleep inducers.

REFERENCES:
patent: 3176009 (1965-03-01), Bell
patent: 3296249 (1967-01-01), Bell
patent: 3340253 (1967-09-01), Reeder et al.

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