Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2005-11-03
2010-10-05
Anderson, Rebecca L (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
active
07807829
ABSTRACT:
The present invention is concerned with a process for the preparation of the compound {3-[2(R)-[(1R)-1-[3,5-bis(tri-fluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)-morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid, and pharmaceutically acceptable salts thereof. This compound is useful as a substance P (neurokinin-1) receptor antagonist. In particular, the compound is useful e.g., in the treatment of emesis and inflammatory diseases.
REFERENCES:
patent: 5691336 (1997-11-01), Dorn et al.
patent: 5780467 (1998-07-01), Dorn et al.
J. J. Hale et al., “Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs”, J. Med. Chem., 2000, vol. 43, pp. 1234-1241.
T. D. Nelson et al., “Tetrabenzyl Pyrophosphate [{Diphosphoric Acid, Tetrakis (phenylmethyl) ester}]”, Organic Syntheses, 2000, vol. 80, p. 219.
Matty Louis
McNamara James Michael
Rosen Jonathan D.
Anderson Rebecca L
Beeler Nicole M.
Merck & Co. , Inc.
Merck Sharp & Dohme Corp.
LandOfFree
Process for {3-[2( R )-[(1 R )-1-[3,5-bis(trifluoromethyl)... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for {3-[2( R )-[(1 R )-1-[3,5-bis(trifluoromethyl)..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for {3-[2( R )-[(1 R )-1-[3,5-bis(trifluoromethyl)... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4208506