Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2003-04-17
2010-12-07
Loewe, Sun Jae Y. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C514S236500
Reexamination Certificate
active
07847095
ABSTRACT:
The present invention is concerned with a novel process for the preparation of the compound 5-[[2(R)-[1(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4 -tria-zol-3-one. This compound is useful as a substance P (neurokinin-1) receptor antagonist. In particular, the compound is useful e.g., in the treatment of psychiatric disorders, inflammatory diseases and emesis.
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CRC Handbook of Chemistry and Physics 80thEdition, CRC Press, 1999, p. 15-18.
Hands David
Huffman Mark
Kaba Mahmoud S.
Payack Joseph F.
Beeler Nicole M.
Loewe Sun Jae Y.
Merck Sharp & Dohme Corp.
Muthard David A.
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