Process for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics

Details Process for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics Process for 2-(1-oxo-3-thiolanyl)-2-penem antibiotics

1988-09-21

1989-09-26

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540357, 514192, 514195, C07D49900, A61K 31545

Patent

active

048701700

ABSTRACT:
Process and intermediates for the conversion of 3R,4R-4-acetoxy-3-[1R-1-(silyloxy)ethyl]-2-acetidinones to antibacterial 5R,6S-6-(1R-1-hydroxyethyl)-2-(1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids, and the pharmaceutically-acceptable salts and pivaloyloxymethyl esters thereof.

REFERENCES:
patent: 4530793 (1985-07-01), Girijavallabhan et al.
patent: 4619924 (1986-10-01), Hamanaka
patent: 4794179 (1988-12-01), Volkmann et al.

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