Process control system for fed-batch fermentation using a comput

Details Process control system for fed-batch fermentation using a comput Process control system for fed-batch fermentation using a comput

1994-08-12

1997-01-21

Rollins, John W.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

364130, 364178, 364550, 364579, 4352401, 4352861, 4352865, 4352871, 4352891, C12N 100, C12N 500, G05B 2102, G05B 2302

Patent

active

055959059

ABSTRACT:
A method for controlling nutrient concentration levels in a fermentation broth containing bacteria or a yeast and a nutrient is disclosed. A computer calculates the nutrient consumption rate of the broth for selected intervals of time between successive samples in real time by comparing the nutrient concentrations of the samples. Thus, the computer having the capability to predict an estimated rate at which the nutrient concentration is expected to decrease at selected sample intervals. Further, adding fresh nutrient to the fermentation broth at a rate and quantity based on the estimated rate to control nutrient concentration levels. Furthermore, a means for obtaining a series of samples and measuring nutrient concentrations is also disclosed.

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