Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-05-26
1998-01-20
Fitzgerald, David L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 6958, 4353201, 43525233, 530412, 530415, 530416, 536 234, 536 2352, 536 241, C12N 1570, C12N 1521
Patent
active
057100276
ABSTRACT:
Methods and vectors for expressing interferon-alpha (IFN-.alpha.) proteins in E. coli are provided. Use of a vector comprising an IFN-.alpha. sequence fused to an E. coli heat-stable enterotoxin signal sequence (STII) under the control of the E. coli phosphatase (phoA) promoter affords high levels of correctly-folded and -processed, biologically active IFN-.alpha. polypeptides.
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Bodo Gerhard
Falkner Edgar
Hauptmann Rudolf
Maurer-Fogy Ingrid
Voss Tilman
Boehringer Ingelheim International GmbH
Fitzgerald David L.
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