Process and system for producing sterile water and sterile aqueo

Details Process and system for producing sterile water and sterile aqueo Process and system for producing sterile water and sterile aqueo

1984-02-10

1986-09-09

Spear, Frank

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210641, 210651, 210259, 2104332, B01D 1300

Patent

active

046107908

ABSTRACT:
Water substantially free of pyrogens and microorganisms that meets the requirements of United States Pharmacopoeia Standard USP XX Water for Injection is produced by processing drinking quality water through a filtration step adapted to remove organic contaminants and impurities that degrade downstream seperation membranes, a reverse osmosis step to remove dissolved solids, pyrogens, microorganisms and chemical contamination, a deionization step to further remove dissolved solids, and an ultrafiltration step to remove pyrogens. A sterile filter to remove microorganisms increases the water quality to USP XX Sterile Water for Injection. Means are provided to periodically remove accumulated chemical contaminants, pyrogens and microorganisms from the reverse osmosis apparatus, the deionization apparatus and the ultrafiltration apparatus. The sterile water can be admixed with a sterile concentrate composition to produce a sterile dilute solution that can be packaged under sterile conditions.

REFERENCES:
patent: 3352779 (1967-11-01), Austin et al.
patent: 3774763 (1973-11-01), Yall et al.
patent: 3836458 (1974-09-01), Wallis et al.
patent: 4072610 (1978-02-01), Gow et al.
patent: 4342651 (1982-08-01), Ahrehs
patent: 4360435 (1982-11-01), Bellamy et al.
Amicon Selection Guide and Catalog, 3 pages, received in PTD 12-8-78.
Devaney, Defensive Publication, T921,001, published 4-2-74.

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