Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...
Reexamination Certificate
2007-07-03
2007-07-03
Chan, Christina (Department: 1644)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
C530S502000, C514S411000, C514S454000
Reexamination Certificate
active
09788888
ABSTRACT:
Endothelial cells have the natural property of releasing soluble factors into the fluid surrounding them, said factors altering the behavior of immune cells. In cell systems containing at least endothelial cells, the release of this type of factor, which promotes the proliferation of resting and weakly activated lymphocytes and at the same time inhibits the proliferation of highly activated lymphocytes and transformed lymphoblasts without impairing their other vital functions, is induced by administration of pentacyclic oxindole alkaloids but inhibited by the concurrent administration of tetracyclic oxindole alkaloids.
REFERENCES:
patent: 4844901 (1989-07-01), Keplinger et al.
patent: 5302611 (1994-04-01), Keplinger et al.
patent: 5723625 (1998-03-01), Keplinger et al.
patent: B 118 4897 (1962-01-01), None
patent: 0 665 231 (1994-01-01), None
patent: 1056537 (1967-01-01), None
patent: 1056863 (1967-02-01), None
patent: 03016695 (1991-02-01), None
patent: 04118580 (1992-05-01), None
patent: WO 82/01130 (1982-04-01), None
patent: WO 86/00524 (1986-01-01), None
patent: WO 90/13027 (1990-11-01), None
patent: WO 91/09035 (1991-06-01), None
patent: WO 95/21169 (1995-08-01), None
Raymond-Hamet et al. Academies des Sciences, Seance du 8 Septembre 1952, 547-550.
Chau et al. (1966) Alkaloids of Uncaria pteropoda. Isolation and structures of pteropodine and Isopteropodine. J. Chem. Soc. 1966, 2245-2249.
Johns et al. (1966) Uncaria alkaloids. two stereoisomers of mitraphylline from Uncaria bernysii and U. ferrea. Tetrahedron Letters 40, 4883-4888.
Becham et al. (1967) The stereochemistry of oxindole alkaloids, uncarines A, B (formasine), C (pteropodine), D (speciophylline), E (Isopteropodine) and F. Aust. J. Chem. 21, 491-504.
Hart et al. (1967) Uncarine C, D (Speciophylline), E, and F: C-3 and C-7 epimeric oxindoles related to tetrahydroalstonine. Chem. Comm. 2, 87-88.
Chan, K.C.. (1968) Gambirdine and Isogambridine. the alkaloids from Uncaria gamir (Hunt.) ROXB. Tetrahedron Letters 30, 3403-3406.
Merlini et al. (1972) Indole alkaloids from Uncaria gambir. Phytochemistry 11, 1525-1526.
Phillipson et al. (1973) Alkaloids of Uncaria longiflora. Phytochemistry 12, 2791-2794.
Phillipson et al. (1973) Indole and oxindole alkaloids from Uncaria bernaysia. Phytochemistry 12, 1481-1487.
Phillipson et al. (1973) Oxindole alkaloids from Uncaria macrophylia. Phytochemistry 12, 2795-2798.
Hemingway et al. (1974) Alkaloids from S. America species of Uncaria (Rubicaeae). J. Pharm. Pharmacol. 26, 113 P.
Phillipson et al. (1974) Augustine and related alkaloids from species of Mitragnya, Nauclea, Uncaria and Strychnos. Phytochemistry 13, 973-978.
Montengro de Matta, S. (1975) Alkaloids and proclanidins of an Uncaria Sp. from Peru. II Farmaco 31, 527-535.
Nozoye et al. (1975) Studies on Uncaria alkaloid. XXI Separation of Rhynchophylline and corynoxeine. Journal of the Pharmaceutical Society of Japan 95, 758-759.
Phillipson et al. (1975) Alkaloids of Uncaria attenuate, U. orientalis and U. canescens. Phytochemistry 14, 1855-1863.
Phillipson et al. (1975) Chromatographic and spectroscopic methods for the Identification of alkaloids from Herbarium samples of the genus Uncaria. J. of Chromatography 105, 163-178.
Almi, N.; Yamanaka, E.; Shinma, N.; Fjiu, M.; Kurita, J.; Sakai, S.; Haginiwa, J. (1977) Studies on plants containing indole alkaloids. VI. Minor bases of Uncaria rhynchophylia Mlq. Chemical Pharmaceutical Bulletin 25, 2067-2071.
Ponglux, G., Tantivatana, P., Pummangura, S. (1977) Alkaloids from the leaves of Uncaria homomalia. Planta Medica 31, 26-30.
Herat et al. (1978) Alkaloids and other constituents f Uncaria eliptica nad Canthium dioccum. Phytochemistry 18, 1385-1387.
Herath, W.H.M.W., Sultanbawa, M.U.S., Wannigama, G.P. (1978) Chemical Investigation of Ceylonese plants. Part 33. Three new ursene carboxylic acids from Uncaria thwaltesil. Phytochemistry 17, 1979-1981.
Tantivatana, P., Ponglux, D., Jirawongse, V., Silpvisavanont, Y. (1979) Alkaloids from Uncaria quadrangularis. Planta Medica 35, 92-94.
Tantivatana, P., Ponglux, D., Wongseripiptana S., Phillipson, J.D. (1980) Alkaloids of Uncaria. Part 7. Alkaloids of U. attenuate (U. salacceusis) from N.E. Thailand. Planta Medica 40, 299-301.
Almi, N., Shito, T., Fukushima, K., Ital, Y., Aoyama, C., Kunisawa, K., Sakai, S., Haginiwa, J., Yamasaki, K. (1982) Studies on plants containing indole alkaloids. VIII. Indole alkaloid glycosides and other constituents of the leaves of Uncaria rhynchophylia Miq. Chemical Pharmaceutical Bulletin 30, 4046-4051/
Phillipson et al. (1982) Separation of heteroyohimbine and oxindole alkaloids by reversed-phase high-performance liquid chromatography. Journla of Chromatography 244, 91-98.
Lavault, M., Moretti, C., Bruneton, J. (1983) Alkaloids of Uncaria gulanensis. Planta Medica 47, 244-245.
Phillipson, J.D., Supavita, N. (1983) Alkaloids from Uncaria species. Part 8. Alkaloids of Uncaria elliptica. Phytochemistry 22, 1809-1813.
Yamanaka, E., Kimizuka, Y., Aimi, N., Sakai, S., Haginiwa, J. (1983) Studies of plants containing indole alkaloids. IX. Determination of tertiary alkaloids in various parts of Uncaria rhynchophylla Miq. Journal of the Pharmaceutical Society of Japan 103, 1028-1033.
Kanatani, H., Kohda, H., Yamasaki, K., Hotta, I., Nakata, Y., Segawa, T., Yamanaka, E., Aimi, N., Sakai, S. (1985) The active principles of the branchlet and hook of Uncaria sinensis Ollv. examined with a 5-hydroxytryptamine receptor binding assay. Journal of Pharmacy and Pharmacology 37, 401-404.
Wagner, H., Kreutzkamp, B., Jurcic, K. (1985) Alkaloids from Uncaria tomentosa and their phagocytosis enhancement effect Planta Medica 419-423.
Kawazoe et al. (1987) Cultivation and breeding of Uncaria rhynchophylla. Journal of Pharmaceutical Science 76, 203P.
Ponglux, D., Wongserlpipatana, S., Aimi, N., Nishimura, M., Ishikawa, M., Sada, H., Haginiwa, J., Sakai, S. (1990) Structure and synthesis of two new types of exindole alkaloids from Uncaria salacensis. Chemical Pharmaceutical Bulletin 38, 573-575.
Kam, T.S., Lee, K.H., Goh, S.H., (1991) Studies on Malaysian Uncaria. Part 4. Dimeric indole alkaloids from Uncaria callophyllia. Phytochemistry 30, 3441-3444.
Arbain, D., Byrne, L.T., Putra, M.M., Sargent, M.V., Syarif, M. (1972) A new glucoalkaloid from Uncaria glabrata. Journal of the Chemical Society, Perkin Transactions 1 665-666.
Kam, T., Lee, K.H., Goh, S.H. (1992) Studies on Malaysian Uncaria. 5. Alkaloid distribution in Malaysian Uncaria. Phytochemistry 31, 2031-2034.
Kawazoe, S., Kobayashi, S., Mizukami, H., Ohashi, H. (1992) Effect of soil moisture content on growth, crude drug “Cho-to-ko” yield, and oxindole alkaloid content of Uncaria rhynchophylla. Sci. Rep. Kyoto Prefectural University 43, 31-34.
Stuppner et al. HPLC-Analyse der Oxindolalkaloide aus Uncaria tomentosa. Scientia Pharmaceutica 60, 168P.
Stuppner, H., Sturm, S., Konwalinka, G. (1992a) Capillary electrophoretic analysis of oxindole alkaloid from Uncaria tomentosa. Journal of Chromatography 609, 375-380.
Strippner, H., Sturm, S., Konwalink, G. (1992b) HPLC analysis for the main oxindole alkaloids from Uncaria tomentosa. Chromatographia 34, 597-600.
Arbain et al. (1993) The Alkaloids of Uncaria glabrata. Aust. J. Chem. 46, 863-872.
Liu, H., Feng, X. -(1993) Oxindole alkaloids from Uncaria sinensis. Phytochemistry 33, 707-710.
Seki et al. (1993) A nuclear magnetic resonance study on the eleven steroisomers of Heteroyohimbine-type oxindole alkaloids. Chem. Pharm. Bull 41, 2077-2086.
Stuppner, H., Sturm, S., Gelsen, G., Zillan, U., Konwalinka, G. (1993) A differential sensitivity of oxindole alkaloids to normal and leukemic cell lines. Planta Medica 59, Supplement, A 583.
Laus, g., Keplinger, D. (1994) Separation of stereoisomeric oxindole alkaloids from Uncaria tomentosa by high performance liquid chromatography. Journal of Chromatography A 662, 243-249.
Wu, T., Chan, Y. (1994) Constituents of leaves of Uncaria hirsuta Haviland. Journal of the Chinese Chemical Society 41, 209-212.
Laus, G., Teppner, H. (1996) The alkaloids of an Uncaria rhynchophlia
Keplinger Klaus
Laus Gerhard
Wurm Martin
Chan Christina
Greenberg Laurence A.
Huynh Phuong N.
Locher Ralph E.
Stemer Werner H.
LandOfFree
Process and substances for the release of a... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process and substances for the release of a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process and substances for the release of a... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3757081