Process and solvate of 2-methyl-thieno-benzodiazepine

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

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C07D24310, C07D49504

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active

057032327

ABSTRACT:
The invention provides lower alcohol solvates of (olanzapine) and a process for making such lower alcohol solvates of olanzapine. The invention provides a method for using such solvates of olanzapine to prepare substantially pure anhydrous Form I 2-methyl-thieno-benzodiazepine.

REFERENCES:
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patent: 4115574 (1978-09-01), Chakrabarti et al.
patent: 4237279 (1980-12-01), Fisher
patent: 5229382 (1993-07-01), Chakrabarti et al.
patent: 5439888 (1995-08-01), Shuman et al.
J. K. Chakrabarti et al., J. Med. Chem., 23, (1980), 878-884.

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