Process and reagent for the specific determination of pancreatic

Details Process and reagent for the specific determination of pancreatic Process and reagent for the specific determination of pancreatic

1993-08-20

1995-12-05

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536 172, 536 174, 536 184, 514 25, C07H 1500

Patent

active

054730589

ABSTRACT:
The present invention provides a process for the specific determination of pancreatic .alpha.-amylase in the presence of salivary .alpha.-amylase in body fluids by reaction with a system for the detection of .alpha.-amylase with the use of an inhibitor for salivary .alpha.-amylase, wherein, as substrate, there is used a compound of the general formula:-- ##STR1## in which R.sub.1 is a straight-chained or branched alkyl or alkoyl radical containing up to 6 carbon atoms, a cycloalkyl or cycloalkoxyl radical containing 3 to 6 carbon atoms or a benzoyl, benzyl or phenyl radical which is optionally hydrophilically substituted, R.sub.2 is a hydrogen atom or in which R.sub.1 and R.sub.2 together form a methylene bridge, the hydrogen atoms of which, independently of one another, can each be substituted by an alkyl radical containing up to 5 carbon atoms or a phenyl radical, n is 1, 2 or 3 and X is an optically determinable residue. The present invention also provides a reagent for the specific determination of pancreatic .alpha.-amylase, as well as new compounds for use in the above process and reagent.

REFERENCES:
patent: 4316983 (1982-02-01), Bollag et al.
patent: 4454315 (1984-06-01), Sasaki et al.
patent: 4612304 (1986-09-01), Fukushi
patent: 4963479 (1990-10-01), Chavez et al.

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