Process and reagent for the determination of the luteinizing hor

Details Process and reagent for the determination of the luteinizing hor Process and reagent for the determination of the luteinizing hor

1992-06-29

1993-09-28

Rosen, Sam

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 793, 435 795, 435 7021, 43524027, 436536, 436548, 5303881, 53038824, 53038815, C12Q 100

Patent

active

052485935

ABSTRACT:
The present invention provides an immunological process for the determination of the luteinizing hormone (LH), wherein at least one monoclonal antibody is used which is directed against LH and cross-reacts with other glycoprotein hormones to an extent of less than 3%.
The present invention also provides a reagent for the determination of the luteinizing hormone, wherein it contains at least one monoclonal antibody which is directed against LH and cross-reacts with other glycoprotein hormones to an extent of less than 3%.
Furthermore, the present invention provides a monoclonal antibody against the luteinizing hormone and a process and a hybridoma cell line for producing it.

REFERENCES:
patent: 4722899 (1988-02-01), Hamaoka et al.
patent: 4792528 (1988-12-01), Canfield et al.
Chow et al., Chemical Abstracts, 103:116420m, 940 (1985).
Rathnam et al., Clin. Chem. 30(5):665-671, "A Sandwich Solid-Phase Enzyme Immunoassay For Lutropin In Urine", (May 1984).
Sevier et al., Clin. Chem: 27(11); 1797-1806, "Monoclonal Antibodies In Clinical Immunology", (1981).
Federici et al., Federation Proceedings, 41(3): 596, Abstract 1907, "Production and Characterization of Monoclonal Antibodies To Human Luteinizing Hormone"(1982).
Soos et al., Chem. Abst. vol. 99 (1983), p. 187909n.

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