Chemistry: analytical and immunological testing – Hemoglobin – myoglobin – or occult blood
Patent
1984-04-19
1987-09-22
Kepplinger, Esther M.
Chemistry: analytical and immunological testing
Hemoglobin, myoglobin, or occult blood
436 67, 436175, 435 28, G01N 3372, C12Q 128
Patent
active
046955526
ABSTRACT:
The present invention provides a process for the determination of the hemoglobin-haptoglobin complex in the presence of free hemoglobin by utilization of the different peroxidate properties of free and of bound hemoglobin, wherein, for the selective inhibition of the peroxidase activity of the free hemoglobin, a detergent is added and the residual peroxidate activity of the reaction mixture is measured.
The present invention also provides a reagent for carrying out this process wherein, besides the substances required for the determination of the peroxidase activity, it contains a detergent for the inhibition of the peroxidase activity of free hemoglobin.
Furthermore, the present invention provides a process for determining the haptoglobin content of a sample, as well as a process for determining glycosilated hemoglobin in a sample.
REFERENCES:
patent: 4353984 (1982-10-01), Yamada et al.
patent: 4517287 (1985-05-01), Scheibe et al.
Kawamura, K. et al., Biochim. Biophys. Acta., 285 (1972), pp. 22-27.
Sawicki, E. et al. Anal. Chem., vol. 33, No. 6, May 61, pp. 722-725.
Deeg Rolf
Schmitt Urban
Ziegenhorn Joachim
Boehringer Mannheim GmbH
Kepplinger Esther M.
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