Process and reagent for the determination of low density lipopro

Details Process and reagent for the determination of low density lipopro Process and reagent for the determination of low density lipopro

1994-12-28

1996-07-02

Hutzell, Paula K.

Chemistry: analytical and immunological testing

Involving immune complex formed in liquid phase

Separation of immune complex from unbound antigen or antibody

436518, 436547, 436 71, 436815, 435793, 435 11, 435962, 5303893, 5303911, G01N 33539, G01N 33543, G01N 3392

Patent

active

055321720

ABSTRACT:
The present invention provides a process for the determination of low density lipoproteins (LDL) in body fluids, wherein high density lipoprotein (HDL) antibodies are added to a sample to be investigated, insolubles formed are separated off and the LDL or one of its components is determined in the supernatant. The present invention also provides a reagent for the determination of the LDL fraction in body fluids, wherein it contains HDL antibodies.

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patent: 4399217 (1983-08-01), Holmquist et al.
patent: 4521519 (1985-06-01), Draeger et al.
patent: 4544630 (1985-10-01), Zugenhorne et al.
Milne et al "Characterization of Monoclonal Antibodies against Human Apolipoprotein E" J. Clin. Invest. 68:111-7, 1981.
Chajek et al., "Isolation and Characterization of a Human Serum Cholesterol Ester Transfer Protein" PNAS, 75(7):3445, 1978.
Naito, H. in Clinical Laboratory Annual, vol. 3 (Eds. H. Homberger and J. Batsakis), pp. 271-282, 1984.
Mangold, H. K. et al. Clinical Biochemistry Principles and Methods, vol. 11, (Eds. Curtis & Roth) pp. 1009-1017, 1978.

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