Process and microorganisms for producing mitomycin A by fermenta

Details Process and microorganisms for producing mitomycin A by fermenta Process and microorganisms for producing mitomycin A by fermenta

1982-09-03

1987-06-16

Rosen, Sam

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435886, 435253, C12P 1718, C12R 1465, C12N 120

Patent

active

046736450

ABSTRACT:
A process for producing mitomycin A by fermentation, which involves culturing a microorganism belonging to the genus Streptomyces, which is capable of producing mitomycin A and having at least one property of (1) deficiency in an ability to produce mitomycin C and (2) a resistance to tryptophan analog, in a culture medium forming and accummulating mitomycin A in the culture medium; and recovering mitomycin A therefrom. The microorganism preferably involves Streptomyces caespitosus T-17-135 (NRRL 12508) or Streptomyces caespitosus (NRRL 12513).

REFERENCES:
patent: 3660578 (1972-05-01), Hata et al.
patent: 4264504 (1981-04-01), Urakawa et al.
Chemical Abstracts, vol. 88, No. 1, 1978, p. 418, Abstract No. 4686t, Abou-Zeid et al.
Umezawa, Index of Antibiotics from Actinomycetes, Tokyo, University of Tokyo Press, 1967, p. 421.
Antibiotics vol. IV: Biosynthesis, Corcoran (ed.), New York, Springer-Verlag, 1981, pp. 295-312.
Wang et al., Fermentation and Enzyme Technology, Wiley & Sons, New York, (1979), pp. 34, 52-53.
Stanier et al., The Microbial World, Prentice Hall, Englewood Cliffs, New Jersey, 1976, pp. 433-434.

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