Process and intermediates for the synthesis of LHRH antagonists

Details Process and intermediates for the synthesis of LHRH antagonists Process and intermediates for the synthesis of LHRH antagonists

1996-03-19

1998-01-20

Tsang, Cecilia J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

530328, 530330, 530331, 530333, 530338, 530339, 562562, 562575, A61K 3804, C07K 400, C07K 102

Patent

active

057102473

ABSTRACT:
A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.

REFERENCES:
patent: 5110904 (1992-05-01), Haviv et al.
patent: 5502035 (1996-03-01), Haviv et al.
Methods Neurosciences, vol. 34 (1993), pp. 3-18, F. Haviv et al., "Synthetic Approaches to Incorporation of Novel Amino Acids in to Gonadotropin Releasing Hormone Peptides".
Int. J. Peptide & Protein Research, vol. 41, No. 4 (1993), pp. 342-346, H. B. Arzen et al., "Temporary Serine Protection in Solid Phase Synthesis of LHRH Analogs".
J. Peptide Science, vol. 1, No. 2 (1995), pp. 89-105, G.A. Flouret, et al., "Antiovulatory Antagonists of LHRH related to Antide".

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