Process and intermediates for the preparation of penem derivativ

Details Process and intermediates for the preparation of penem derivativ Process and intermediates for the preparation of penem derivativ

1983-06-10

1986-10-28

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540310, 540357, 540359, 540360, C07D20508, C07D40312, C07D49804, C07D40112

Patent

active

046197834

ABSTRACT:
Certain substituted-2-penem-3-carboxylic acid compounds, and pharmaceutically-acceptable salts thereof, can be prepared from the appropriate xanthate or trithiocarbonate by desulfurization, followed by halogenation and ring closure. The corresponding desulfurized and halogenated intermediates are disclosed.

REFERENCES:
Kametani, Chem Abs 91, 39213u (1979).
Reese et al, "Protective Groups in Organic Chemistry" (pp. 95-142), 1973.
Haines, Adv. Carbohydrate Chem 33, 11-109 (1976).
Hayashi et al., 2-(Alkylthio)penem-3-carboxylic Acids. V., Chem. Pharm. Bull., 29(11), 3158-3172 (1981).
Yoshida et al., 2-(Alkylthio)penem-3-carboxylic Acids. IV., Chem. Pharm. Bull., 29(10, 2899-2909 (1981).
Volante, A, New Highly Efficient Method for the Conversion of Alcohols to Thioesters and Thiols, Tetrahedron Letters, 22(33), 3119-3122 (1981).
Oida et al., 2-(Alkylthio)penem-3-carboxylic Acids. II., Chem. Pharm. Bull., 28(11), 3258-3264 (1980).
DeNinno, et al., A Convenient Synthesis of Racemic 6-Hydroxyethyl-2-Alkylthio-Substituted Penems, Tetrahedron Letters, 28(35), 3535-3538 (1982).
Tanaka et al., 2-Thioxopenams, Useful Intermediate for Penem Synthesis,Chem. Comm., 1982(13), 713-714 (1982).
J. L. Wardell, Preparation of Thiols, in the Chemistry of the _Thiol Group, S. Patai, Ed., John Wiley & Sons, London, 1974, Chapt. 4.
A. Afonso, et al., New Synthesis of Penems, the Oxalimide _Cyclization Reaction, J. Amer. Chem. Soc., 104, 6138-6139(1982).

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