Process and intermediates for the preparation of excitatory amin

Organic compounds -- part of the class 532-570 series – Organic compounds – Silicon containing

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564123, 564161, 564162, 564199, 564204, 564210, 564211, 564463, 564500, 564502, 560 12, 560 19, 560 24, 560 41, 560149, 560155, 560157, C07F 704, C07F 710

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056706847

ABSTRACT:
The present invention provides novel intermediates which are useful for the preparation of excitatory amino acid receptor antagonists. Further provided is a process to enatioselectively prepare hydroisoquinoline compounds with central nervous system activity.

REFERENCES:
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Moriwake, J Org Chem, 1989, vol. 54, pp. 4114-4120 1989.
S. R. Wilson, et al., J. Org. Chem. 1991, 56, 4766-4772.
S. Wattanasin, et al., J. Org. Chem., 1985, 50, 3810-3815.
S. F. Martin, et al., J. Org. Chem., 1983, 48, 5170-5180.
T. Moriwake, J. Org. Chem., 1989, 54, 4114-4120.
Melikian-Badalian and Ornstein, LRL News, Mar. 1992 p. 31.
J. Levy, et al., Tetrahedron Letters, 1988, 29, 3303.

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