Process and intermediates for the preparation of 3(1H-tetrazol-5

Details Process and intermediates for the preparation of 3(1H-tetrazol-5 Process and intermediates for the preparation of 3(1H-tetrazol-5

1982-09-09

1984-10-02

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

546276, C07D47104, C07D40112

Patent

active

044749538

ABSTRACT:
A process for preparing compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently selected from the group consisting of H, an alkyl group containing 1 to about 4 carbon atoms, an alkoxy group containing 1 to about 4 carbon atoms and halogen. The process involves reacting together a 2-aminopyridine, an alkyl tetrazol-5-ylacetate, and a trialkyl orthoformate and cyclizing the resulting intermediate.

REFERENCES:
patent: 3585198 (1971-06-01), Meszaros et al.
patent: 3960847 (1976-06-01), Yale
patent: 4122274 (1978-10-01), Juby
patent: 4209620 (1980-06-01), Juby
patent: 4223031 (1980-09-01), Covington et al.
Meszaros et al., Arzneim-Forsch. 22, 815-829 (1972).
Finnegan et al., J. Am. Chem. Soc., 80, 3908-3911 (1958).
Yevich et al., J. Med. Chem. 25, 864-868 (1982) (Jul. issue).

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