Process and intermediates for manufacture of 3-(5-amino-1-carbox

Details Process and intermediates for manufacture of 3-(5-amino-1-carbox Process and intermediates for manufacture of 3-(5-amino-1-carbox

1984-10-18

1986-07-15

Bond, Robert T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D22316, C07D40112

Patent

active

046005340

ABSTRACT:
The invention concerns a novel process for the preparation of 3-(5-amino-1-carboxypentylamino)-tetrahydro-1-benzazepin-2-one-1-acetic acid by opening, preferably under acidic conditions, the caprolactam ring in a compound of formula II ##STR1## wherein COR represents carboxy or esterified carboxy, and hydrolyzing the esterified carboxy group if present. The preparation of the starting materials of formula II is described.

REFERENCES:
patent: 4473575 (1984-09-01), Watthey

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