Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
2000-01-20
2000-09-26
Rotman, Alan L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
5462844, 546309, 546310, 546311, C07F 702, C07D40502, C07D21174, C07D21353
Patent
active
061244570
ABSTRACT:
The instant invention relates to intermediates of Formula II, ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification, and to processes for preparing such intermediates. This invention also relates to processes for preparing compounds of Formula III, ##STR2## and enantiomers thereof, wherein R.sup.2, R.sup.3 and R.sup.4 are as defined in the specification. Compounds of Formula II and Formula III are intermediates in the preparation of a potent .beta..sub.3 adrenergic receptor agonist. The instant invention also relates to processes for preparing the .beta..sub.3 adrenergic receptor agonist using the compounds of Formula II and Formula III.
REFERENCES:
patent: 5714506 (1998-02-01), Fisher et al.
patent: 6001856 (1999-12-01), Dow
E. J. Corey, et al., A Catalytic Enantioselective Synthesis of Denopamine, a Useful Drug for Congestive Heart Failure, 1991.
Paul R. Brodfuehrer, et al., Asymmetric Synthesis of the Antiarrhythmia Agent d-Sotalol, 1997, Am. Chem. Society and Royal Society of Chemistry, pgs. 176-178.
DeVries Keith M.
Raggon Jeffrey W.
Shanker Ravi M.
Urban Frank J.
Vanderplas Brian C.
Benson Gregg C.
Desai Rita
Pfizer Inc.
Richardson Peter C.
Ronau Robert T.
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