Process and intermediate for the purification of oxytetracycline

Details Process and intermediate for the purification of oxytetracycline Process and intermediate for the purification of oxytetracycline

1993-10-20

1995-02-07

Mars, Howard T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Tetracyclo naphthacene configured ring system having at...

552206, C07C23388, C07C23542

Patent

active

053877039

ABSTRACT:
The invention relates to a new process for obtaining a completely pure oxytetracycline which does not contain any acetyldecarboxamidooxytetracycline as ingredient. In glacial acetic acid there is suspended under stirring oxytetracycline hydrochloride, or alternatively, oxytetracycline dihydrate under addition of an equimolar quantity of hydrogen chloride in the form of concentrated hydrochloric acid. The stirring is continued for 5 hours, the formed oxytetracycline hydrochloride acetate precipitate is filtered, washed with glacial acetic acid and acetone, whereupon it is dried under reduced pressure at a temperature up to 40.degree. C. till constant weight. Oxytetracycline hydrochloride acetate ##STR1## is a new compound and may be used as intermediate in the above process.

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