Process and intermediate for the preparation of 2-hydroxy-3-sulf

Details Process and intermediate for the preparation of 2-hydroxy-3-sulf Process and intermediate for the preparation of 2-hydroxy-3-sulf

1995-04-24

1997-12-02

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562426, C07C31500, C07C31700

Patent

active

056938578

ABSTRACT:
##STR1## This invention relates to intermediate compounds of formula (VI), wherein: R.sub.1 is (L).sub.a --(CH.sub.2).sub.b --(T).sub.c --B; a is 0 or 1; b is 3 to 14; c is 0 or 1; L and T are independently sulfur, oxygen, CH.dbd.CH, C.tbd.C, or CH.sub.2 ; B is H, C.sub.1-4 alkyl, ethynyl, trifluoromethyl, isopropenyl, furanyl, thienyl, cyclohexyl or phenyl unsubstituted or monosubstituted by Br, Cl, CF.sub.3, C.sub.1-4 alkoxy, C.sub.1-4 alkyl, methylthio or trifluoromethylthio; R.sub.2 and A are independently selected from H, CF.sub.3, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, F, Cl, Br, I, OH, NO.sub.2 or NH.sub.2 ; or, when R.sub.1 and A are H, R.sub.2 is (L).sub.a --(CH.sub.2).sub.b --(T).sub.c --B wherein a, b, c, L, T and B are as defined above; and M is H, Li, Na, K, NH.sub.4 or an organic ammonium cation, and their use in a process for preparing leukotriene antagonists.

REFERENCES:
patent: 4655189 (1987-04-01), Baker et al.
patent: 4665189 (1987-05-01), Baker et al.
patent: 4820719 (1989-04-01), Gleason et al.
patent: 4874792 (1989-10-01), Gleason et al.
patent: 5110959 (1992-05-01), Flisak et al.
Gleason et al., J. Med. Chem., 30, 959 (1987).
Chong, et al., J. Org. Chem., 50, 1560 (1985).
Sharpless et al., Pure Appli. Chem., 55, 589 (1983).
Liwschitz et al., J. Chem. Soc., 1116 (1962).
Harada et al., Bull. Chem. Soc. Jpn., 47, 2911 (1974).
Harada et al., Bull. Chem. Soc. Jpn., 39, 2311 (1966).
Harada, J. Org. Chem., 31, 1407 (1966).
Mohrig et al., J. Org. Chem., 46, 4655 (1981).

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