Process and intermediate compounds useful in the preparation...

Details Process and intermediate compounds useful in the preparation... Process and intermediate compounds useful in the preparation...

2004-07-23

2008-08-19

Anderson, Rebecca (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07414141

ABSTRACT:
There is provided a process for the preparation of a compound of formula (7) or salts thereof: wherein R1represents a hydrogen or a hydrocarbyl group, R2represents a hydrogen or substituent group, R3represents a hydrogen or a hydrocarbyl group, and X represents a hydrogen or substituent group which comprises a) cyanating a compound of formula (1): wherein Y represents a halo group, preferably CI or Br; P1represents hydrogen or a protecting group, and W represents =0 or —OP2, in which P2represents hydrogen or a protecting group, to give a compound of formula (2): b) reducing the compound of formula (2) to give a compound of formula (3): coupling the compound of formula (3) with a compound of formula (4): to give a compound of formula (5): when W represents —OP2, deprotecting and then oxidising the compound of formula (5) to give a compound of formula (6): and e) subjecting the compound of formula (5) when W represents ═O, or compound of formula (6) to ring-opening, and removal of any remaining protecting groups, to give a compound of formula (7) or salts thereof

REFERENCES:
patent: WO 92/06968 (1992-04-01), None
patent: WO-92/06968 (1992-04-01), None
patent: WO 2004/027075 (2004-04-01), None
patent: WO-2004/027075 (2004-04-01), None
patent: WO 2004/096788 (2004-11-01), None
patent: WO-2004/096788 (2004-11-01), None
Harden, A, caplus AN 1906:833.
Tararov et al., Synthesis of the Chiral Side Chain of Statins—Lactone versul Lactol Pathway, Eur. J. Org. Chem, 2006, 5543-5550.
International Search Report dated Dec. 30, 2004.

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