Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1998-04-06
1999-08-10
Levy, Neil S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424422, 424423, 424428, 424434, 424437, 424444, 424487, 523122, 524 5, 521182, 525415, 6048901, A61K 916
Patent
active
059355948
ABSTRACT:
An improved method or process and device for treating and healing a bone void is disclosed, and in particular a method employing a surfactant for efficiently incorporating a biologically active agent into the interstices (voids or pares) of a porous hydrophobic biodegradable material wherein the biologically active agent is deposited on the internal surfaces defining the voids or pores of the biodegradable material. The biodegradable body or device, now containing surfactant and a biologically active agent in the body itself as well as on the external surfaces and the internal surfaces defining the voids or pores, is than applied into the bone void or cavity.
REFERENCES:
patent: 2465357 (1949-03-01), Correll
patent: 2610625 (1952-09-01), Sifferd et al.
patent: 2621145 (1952-12-01), Sano
patent: 2703316 (1955-03-01), Schneider
patent: 2758987 (1956-08-01), Salzberg
patent: 3463158 (1969-08-01), Schmitt et al.
patent: 3491760 (1970-01-01), Braun et al.
patent: 3636956 (1972-01-01), Schneider
patent: 3688317 (1972-09-01), Kurtz
patent: 3739773 (1973-06-01), Schmitt et al.
patent: 3902497 (1975-09-01), Casey
patent: 3937223 (1976-02-01), Roth
patent: 4164560 (1979-08-01), Folkman et al.
patent: 4181983 (1980-01-01), Kulkarni
patent: 4186448 (1980-02-01), Brekke
patent: 4279249 (1981-07-01), Vert et al.
patent: 4357312 (1982-11-01), Hsieh et al.
patent: 4419340 (1983-12-01), Yolles
patent: 4442655 (1984-04-01), Stroetmann
patent: 4505266 (1985-03-01), Yannas et al.
patent: 4553272 (1985-11-01), Mears
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4563489 (1986-01-01), Urist
patent: 4578384 (1986-03-01), Hollinger
patent: 4596574 (1986-06-01), Urist
patent: 4608199 (1986-08-01), Caplan et al.
patent: 4609551 (1986-09-01), Caplan et al.
patent: 4620327 (1986-11-01), Caplan et al.
patent: 4636526 (1987-01-01), Dorman et al.
patent: 4642120 (1987-02-01), Nevo et al.
patent: 4713076 (1987-12-01), Draenert
patent: 4749585 (1988-06-01), Greco et al.
patent: 4752294 (1988-06-01), Lundgren
patent: 4846835 (1989-07-01), Grande
patent: 4938763 (1990-07-01), Dunn et al.
patent: 4962091 (1990-10-01), Eppstein et al.
patent: 4964868 (1990-10-01), Bloebaum
patent: 5041138 (1991-08-01), Vacanti et al.
patent: 5061281 (1991-10-01), Mares et al.
patent: 5077049 (1991-12-01), Dunn et al.
patent: 5078744 (1992-01-01), Chvapil
patent: 5133755 (1992-07-01), Brekke
patent: 5152791 (1992-10-01), Hakamatsuka et al.
patent: 5288496 (1994-02-01), Lewis
patent: 5294446 (1994-03-01), Schlameus et al.
patent: 5324519 (1994-06-01), Dunn et al.
patent: 5326357 (1994-07-01), Kandel
patent: 5366508 (1994-11-01), Brekke
patent: 5372821 (1994-12-01), Badylak et al.
patent: 5376118 (1994-12-01), Kaplan et al.
patent: 5425639 (1995-06-01), Anders
patent: 5478739 (1995-12-01), Slivka et al.
patent: 5512475 (1996-04-01), Naughton et al.
patent: 5520923 (1996-05-01), Tjia et al.
patent: 5569463 (1996-10-01), Hezmus et al.
patent: 5607474 (1997-03-01), Athanasiou et al.
patent: 5616338 (1997-04-01), Fox, Jr. et al.
patent: 5645084 (1997-07-01), McKay
patent: 5665114 (1997-09-01), Wendock
patent: 5736160 (1998-04-01), Ringeisen et al.
patent: 5830493 (1998-11-01), Yokota et al.
Resorbable Ceramic Implants, G.A. Graves et al., Bioceramics--Engineering in Medicine (Part 1), J. Biomedical Materials Symposium, No. 2, pp. 91-115 (1972).
Application of Porous Ceramics for the Attachment of Load Bearing Internal Orthopedic Applications, J.J. Klawitter et al., Bioceramics--Engineering in Medicine (Part 1), J. Biomedical Materials Symposium, No. 2, pp. 161-129 (1972).
Compatibility of Porous Ceramics with Soft Tissue; Application to Tracheal Prosthesis, S.F. Hulbert et al., Bioceramics--Engineering in Medicine (Part 1), J. Biomedical Materials Symposium, vol. 2, (Part 1), pp. 269-279 (1972).
Bioceramics--Engineering in Medicine (Part 2), J. Biomedical Materials Symposium, R. Topazian et al., No. 2 (Part 2), pp. 311-332 (1972).
Development of Ceramic and Ceramic Composite Devices for Maxillofacial Applications, T.D. Driskell et al., Bioceramics--Engineering in Medicine (Part 2), J. Biomedical Materials Symposium, No. 2 (Part 2), pp. 345-361 (1972).
Effect of the Structure of Poly(Glycol Monomethacrylate) Gel on the Calcification of Implants, L. Sprinel et al., Calc. Tiss., Res. 13, pp. 63-72 (1973).
Calcium Phosphate Ceramics as Hard Tissue Prosthetics, Michael Jarcho, PH.D., Clinical Orthopaedics and Related Research, No. 157, pp. 259-278 (1981).
Developmental Role of Hyaluronate, Bryan P. Toole, Connective Tissue Research, vol. 10, pp. 93-100 (1982).
Effect of fibronectin on the adhesion of an established cell line to a surface reactive biomaterial, T.L. Seitz et al., Journal of Biomedical Materials Research, vol. 16, pp. 195-207 (1982).
Influence of polylactic acid mesh on the incidence of localized osteitis, John H. Brekke et al., Oral Surg., vol. 56, No. 3, pp. 240-245 (1983).
Healing of Hyaluronic Acid-Enriched Wounds: Histological Observations, G. Abatangelo et al., Journal of Surgical Research 35, pp. 410-416 (1983).
Human Bone Morphogenetic Protein, Marshall R. Urist et al., Proceedings of the Society for Experimental Biology and Medicine 173, pp. 194-199 (1983).
Urist et al., Proc. Natl. Acad. Sci. USA, vol. 81, Jan. 1984 pp. 371-375, Purification of Bovine Bone Morphogenetic Protein by Hydroxyapatite Chromatograph.
Beta-tricalcium Phosphate Delivery System for Bone Morphogenetic Protein, Marshall R. Urist et al., Clinical Orthopaedics and Related Research, No. 187, pp. 277-280 (1984).
Effect of Surgical Trauma and Polylactate Cubes and Granules on the Incidence of Alveolar Osteitis in Madibular Third Molar Extration Wounds, John Brekke et al, J. Canad Dent Assn, No. 4, pp. 315-319 (1986).
Repair of Articular Surfaces by Allografts of Articular and Growth-Plate Cartilage, by J.E. Aston et al., The Journal of Bone and Joint Surgery, vol. 68-B, No. 1, Jan. 1986.
Spence, Basic Human Anatomy, 1986, pp. 63-65.
David H. Cormach, "Ham's Histology", Nineth Edition, .COPYRGT.1987, J.B. Lippincutt Company, pp. 325-326.
Sato et al., Pharm. Res., 5 (1), 21-30, 1988, Porous biodegradable microspheres for controlled drug delivery.
The Effect of the Addition of Low Molecule Weight Poly (DL-lactide) on Drug Release from Biodegradable Poly(DL-lactide) Drug delivery Systems, R. Bodmeier et al., International Journal of Pharmaceutics, 51, pp. 1-9 (1989).
Repair of Rabbit Articular Surfaces with Allograft Chondrocytes Embedded in Collagen Gel, by S. Wakitani et al., The Journal of Bone and Joint Surgery, vol. 71-B, No. 1, Jan. 1989, pp. 74-80.
The Repair of Experimentally Produced Defects in Rabbit Articular Cartilage by Autologous Chondrocyte Transplantation, D.A. Grande et al., Journal of Orthopaedic Research, vol. 7, No. 2, 1989.
The use of polylactic acid matrix and periosteal grafts for the reconstruction of rabbit knee articular defects, H.P. von Schroeder et al., Society For Biomaterials, May 20-23, 1990.
In Vivo Osteochondrogenic Potential of Cultured Cells Derived From the Periosteum, H. Nakahara et al., Clinical Orthopaedics, Oct. 1990, vol. 259, pp. 223-232.
Cartilage resurfacing of the rabbit knee, E. Billings, Jr. et al., Acta Orthop Scand 1990; 61(3), pp. 201-206.
Potential of Adult Human Perichondrium to Form Hyalin Cartilage In Vitro, S.K. Bulstra et al., Journal of Orthopaedic Research, vol. 8, No. 3, 1990, pp. 328-335.
The use of demineralized bone and rib perichondrium composite grafts for the repair of full thickness articular defects, H.P. von Schroeder et al., 36th Annual Mtg, Orthopaedic Research Society, Feb. 5-8, 1990, New Orleans.
Reconstruction of rabbit knee articular defects with a polylactic acid matrix, R.D. Coutts et al., Orthopaedic Research Society, Feb. 5-8, 1990.
Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recogniction, by K. Miyake, C.B. Underhill, J. Lesley, and P.W. Kincade, J. Exp. Med., 172, pp. 69-75, (1990).
The use of polylactic acid matrix and periosteal grafts for the reconstruction of rabbit knee articular defects, H.P. von Schroeder et al., Jour
Brekke John H.
Ringeisen Timothy
Kamrath Alan
Levy Neil S.
THM Biomedical, Inc.
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