Process and device for the specific adsorption of heparin

Details Process and device for the specific adsorption of heparin Process and device for the specific adsorption of heparin

1988-11-14

1990-06-19

Rollins, John W.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

536 21, 604 5, 604 6, 435803, 210646, 210927, 514822, 514833, A61K 3514, C08B 3710, A61M 3700

Patent

active

049352040

ABSTRACT:
A process for the specific adsorption of heparin and other heparin-like substances which comprises flowing a buffered solution of whole blood, from which corpuscular blood constituents have been removed, plasma and/or solutions containing whole blood or plasma through an adsorber capsule containing a medium that adsorbs heparin and other heparin-like substances at an acid pH, preferably in the range of 4.0 to 5.5. Preferably, the process is carried out in a closed, extracorporeal circulation and the medium possesses anion exchange resin properties.

REFERENCES:
patent: 3765536 (1973-10-01), Rosenberg
patent: 4048064 (1977-09-01), Clark
patent: 4226599 (1980-10-01), Butler et al.
A. Thompson et al., J. Lab. Clin. Med., 88: 922-929, 1976.

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