Chemical apparatus and process disinfecting – deodorizing – preser – Chemical reactor – Organic polymerization
Reexamination Certificate
2005-03-15
2005-03-15
Soderquist, Arlen (Department: 1743)
Chemical apparatus and process disinfecting, deodorizing, preser
Chemical reactor
Organic polymerization
C422S105000, C422S116000, C422S130000, C422S131000, C536S025300, C536S025310
Reexamination Certificate
active
06866827
ABSTRACT:
In a process and a device for the parallel preparation of at least 4n oligonucleotides, at least four inserts each with n reaction vessels are first arranged on a plate (16), each reaction vessel containing a nucleotide initiator base bound to an inert carrier. Particular operations are then carried out in parallel with one another at four stations (28, 30, 32, 34), and in particular a deblocking operation simultaneously in all n reaction vessels of the insert at the first station (28), a first washing operation simultaneously in all n reaction vessels of the insert at the second station (30), a coupling operation in all n reaction vessels of the insert at the third station (32), and, simultaneously in all n reaction vessels of the insert at the fourth station (34), a second washing operation followed by a capping operation followed by a third washing operation followed by an oxidation operation followed by a fourth washing operation. The plate (16) with the inserts is rotated station by station, the above-mentioned operations being carried out, until the desired oligonucleotides have been formed by coupling individual nucleotides to one another.
REFERENCES:
patent: 4728502 (1988-03-01), Hamill
patent: 5047524 (1991-09-01), Andrus et al.
patent: 5053454 (1991-10-01), Judd
patent: 5368823 (1994-11-01), McGraw et al.
patent: 5462748 (1995-10-01), Lloyd et al.
patent: 5472672 (1995-12-01), Brennan
patent: 5538694 (1996-07-01), Delius
patent: 5807525 (1998-09-01), Allen et al.
patent: 5866342 (1999-02-01), Antonenko et al.
patent: 6264891 (2001-07-01), Heyneker et al.
patent: 6270730 (2001-08-01), McLuen et al.
patent: WO 9511748 (1995-05-01), None
patent: WO 9857181 (1998-12-01), None
patent: WO 9965602 (1999-12-01), None
patent: WO 0018503 (2000-04-01), None
patent: WO 0040330 (2000-07-01), None
Baier et al., “Synthesis and Purification in a Single Column on a High-Throughput Automated Oligonucleotide Production System”,BioTechniques20:298-303 (Feb. 1996).
Metabion Gesellschaft fur angewandte Biotechnologie mbH
Soderquist Arlen
Webb Ziesenheim & Logsdon Orkin & Hanson, P.C.
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