Process and composition using ondansetron

Details Process and composition using ondansetron Process and composition using ondansetron

1993-01-19

1994-09-06

Michl, Paul R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424484, 424464, 424465, A61K 914

Patent

active

053446585

ABSTRACT:
The invention relates to a process for reducing the crystal size of ondansetron hydrochloride dihydrate produced by crystallisation from solvent to a size which is suitable for effective distribution in a tablet blend, in particular 100% less that 250 .mu.m. The ondansetron hydrochloride dihydrate is desolvated by drying at elevated temperature and reduced or atmospheric pressure and is then rehydrated.

REFERENCES:
Sekiguchi et al., Chem. Pharm. Bull., 16(12), 2495-2502, 1968.
Pikal et al., Chemical Abstracts, 100:144884x, 1984.
Shirotani et al., Chemical Abstracts, 96:57633v, 1982.

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