Process and composition for treating hypertension

Details Process and composition for treating hypertension Process and composition for treating hypertension

1994-11-28

1995-09-19

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, C07K 506, A61K 3805

Patent

active

054515718

ABSTRACT:
The present invention is directed to a process for treating hypertension in mammals through the administration of an effective amount of a Z-Pro-prolinal (ZPP) composition. In addition, the present invention is also directed to a pharmaceutical composition for treating hypertension in mammals comprised of an active ingredient, Z-Pro-prolinal (ZPP). It has recently been discovered that Z-Pro-prolinal (ZPP) is a useful inhibitor to the biosynthetic formation of Ang(1-7), a previously unknown biologically active hypertensive agent in the reninangiotensin system (RAS). By administering an effective amount of Z-Pro-prolinal (ZPP), Ang-(1-7) formation may be reduced, resulting in a significant decrease in blood pressure without notable changes in heart rate and other circulatory functions.

REFERENCES:
Kokubu et al., Biochemical Pharmacology, vol. 22, pp. 3217-3223 (1973).
Kono, et al., Life Sciences, 38:1515-1519, 1986.
Schiavone, et al., Proc. Natl. Acad. Sci., U.S.A., 85:4095-4098, Jun. 1988.
Ward, et al., Bioch. Pharm., 36(19):3187-3193, 1987.

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