Process and composition for the purification of amphotericin B

Details Process and composition for the purification of amphotericin B Process and composition for the purification of amphotericin B

1987-10-27

1990-02-20

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 172, 536 185, 514 31, 424123, 424119, 424118, C07H 1708, A01N 4304, A61K 3500, C07G 300

Patent

active

049027891

ABSTRACT:
A unique four-solvent system comprising methanol, dimethylformamide, methylene chloride and water is employed to provide an improved process for the purification and crystallization of amphotericin B.

REFERENCES:
patent: 2908611 (1959-10-01), Dutcher et al.
patent: 3965090 (1976-06-01), Metzger
patent: 4049898 (1977-09-01), Metzger
patent: 4054265 (1977-10-01), Metzger
patent: 4054734 (1977-10-01), Metzger
patent: 4177265 (1979-12-01), Michel et al.
patent: 4308375 (1981-12-01), Tang
The Journal of Antibotic, vol. XXVIII, No. 3, Mar. 1975, p. 244, Falkowski, L., "N-Glycosyl Derivatives of Polyene Macrolide Antibiotics".

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