Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1992-03-26
1994-04-26
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424490, A61K 916
Patent
active
053065077
ABSTRACT:
A product and process for preparing a pharmaceutical composition for forming tablets, the composition containing pamabrom and pyrilamine maleate. In preferred embodiments, the composition also contains acetaminophen. A fluid bed granulator is charged with a first material containing pamabrom or pyrilamine maleate, and a first liquid containing pregelatinized starch is sprayed onto the first material so as to form a barrier coat. The barrier coated material is dried and then further coated with a second liquid containing only one of pamabrom and pyrilamine maleate, whichever was not present in the first material charged to the fluid bed granulator. The further coated material is then dried to a moisture content of from about 0.5% to less than about 2% by weight, so as to form particles in which the pamabrom and pyrilamine maleate are separated by the pregelatinized starch barrier.
REFERENCES:
patent: 2502151 (1950-03-01), Horclois
patent: 2711411 (1955-06-01), Holbert
patent: 2998450 (1961-08-01), Wilbert
patent: 5011688 (1991-04-01), Calam
patent: 5037823 (1991-08-01), Jones
patent: 5085868 (1992-02-01), Mattsson
Merck Index, Entry No. 6865, 10th Ed., p. 1005 (1983).
Merck Index, Entry No. 7883, 10th Ed., p. 1152 (1983).
Merck Index, Entry No. 39, 10th Ed., p. 7 (1983).
Benston W.
Mallinckrodt Specialty Chemicals Company
Page Thurman K.
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