Process and apparatus for the synthesis of peptides by use of n-

Details Process and apparatus for the synthesis of peptides by use of n- Process and apparatus for the synthesis of peptides by use of n-

1974-07-03

1976-04-20

Gotts, Lewis

Textiles: fiber preparation

2601125R, 23253A, 23285, C12D 1300, C07C10352

Patent

active

039517411

ABSTRACT:
Method and apparatus are provided for preparing polypeptides by conjugating arginine as an end group to a polyethyleneimine water soluble polymer, stepwise addition of amino acids as their N-carboxyanhydrides to prepare the desired polypeptide, enzymatic cleavage of the polypeptide with the arginine group from the polyethyleneimine and enzymatic cleavage of the arginine to provide the desired polypeptide. An automated apparatus is provided for performing the above process.

REFERENCES:
patent: 3531258 (1970-09-01), Merrifield et al.
patent: 3557077 (1971-01-01), Brunfeldt et al.
patent: 3647390 (1972-03-01), Kubodera et al.
patent: 3715190 (1973-02-01), Park et al.
patent: 3725010 (1973-04-01), Penhast
patent: 3819607 (1974-06-01), Heuser et al.
patent: 3846399 (1974-11-01), Hirschmann et al.
Halstrom et al., "Peptides 1972," H. Hanson and H. Jakubke, Eds., North Holland Pub. Co., Amsterdam, 1973, pp. 173-179.

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