Process and apparatus for the production of sterile filtered blo

Details Process and apparatus for the production of sterile filtered blo Process and apparatus for the production of sterile filtered blo

1977-05-26

1979-02-27

Sever, Frank

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

210 71, 210 78, 210DIG23, A23J 106, C07G 7026

Patent

active

041418875

ABSTRACT:
A process for the manufacture of sterile filtered blood-clotting products includes the steps of extracting blood from at least one donor, physically separating the blood to obtain substantially purified plasma free of cellular components, deep freezing the purified plasma at a temperature below about minus 22.degree. C. to preserve Factor VIII, thawing the plasma to produce a cryo-precipitate, enriching the cryo-precipitate by physical treatment and physically separating the cryo-precipitate from the thawed plasma. The cryo-precipitate is then dissolved in a buffer and is sterile filtered by means of a static filtration with an autoclaved filtration device at a pressure difference of less than 0.5 atm. An apparatus for carrying out the process is also provided.

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