Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2006-03-21
2006-03-21
Horlick, Kenneth R. (Department: 1637)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
C435S006120, C435S091330, C435S173300, C536S023100, C536S023500
Reexamination Certificate
active
07015017
ABSTRACT:
A process for instabilizing viral quasi-species-distributions under avoidance of resistance phenomena by replication of the nucleic acids of the viruses present in the quasi-species-distribution by of a defective replication system,a)whereby the defective replication system has a rate of misincorporation for nucleotides above the rate of misincorporation of the viral wild-type-replication system and,whereby the viruses are replicated by the replication system having the higher rate of misincorporation at least as effectively as it is done by the replication system of the wild-type virus,b)and/or negative influence of the replication of the consensus-sequence (nucleic acid sequence of the wild-type virus) in relation to other replicatable nucleic acids.
REFERENCES:
patent: 4536398 (1985-08-01), Ito et al.
patent: 6423516 (2002-07-01), Eigen et al.
patent: 0 215 987 (1987-01-01), None
Biebricher Christof
Domingo Esteban
Eigen Manfred
Henco Karsten
Holland John
Collard & Roe P.C.
Evotec Biosystems AG
Horlick Kenneth R.
Tung Joyce
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