Process

Details Process Process

2006-09-15

2010-11-09

Pak, John (Department: 1616)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S489000, C424S490000, C424S491000, C424S497000, C514S002600, C514S003100, C514S004300, C514S170000, C514S171000, C514S172000, C514S174000, C514S182000, C514S613000, C514S625000, C977S773000

Reexamination Certificate

active

07829123

ABSTRACT:
A process for preparing particles of a substance, such as a protein or polypeptide, comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator has a solubility in water which decreases with increasing temperature; and (b) contacting the first liquid with a second liquid comprising a fluid gas and an organic solvent using an anti-solvent fluid gas technique under conditions of temperature and pressure which result in the precipitation of particles comprising the substance, wherein the temperature of the first liquid is at or above the cloud point temperature of the first liquid when the first liquid contacts the second liquid. Also claimed are particles obtained according to the process and compositions containing the particles.

REFERENCES:
patent: 5346702 (1994-09-01), Na et al.
patent: 5639441 (1997-06-01), Sievers et al.
patent: 6299906 (2001-10-01), Bausch et al.
patent: 6998051 (2006-02-01), Chattopadhyay et al.
patent: 7276184 (2007-10-01), Irvin et al.
patent: 2005/0181041 (2005-08-01), Goldman
patent: 2006/0029676 (2006-02-01), Sun
patent: 0677332 (1995-10-01), None
patent: 9013285 (1990-11-01), None
patent: 9501221 (1995-01-01), None
patent: 9600610 (1996-01-01), None
patent: 9714407 (1997-04-01), None
patent: 9836825 (1998-08-01), None
patent: 9944733 (1999-09-01), None
patent: 9952507 (1999-10-01), None
patent: 9959710 (1999-11-01), None
patent: 0030613 (2000-06-01), None
patent: 0037169 (2000-06-01), None
patent: 0103821 (2001-01-01), None
patent: 0115664 (2001-03-01), None
Winters et al., Precipitation of Proteins in Supercritical Carbon Dioxide, 1996, J. Pharm Sci, 85, 586-594.
Jackson et al., Beware of Proteins in DMSO, Biochem et Biophysica Acta 1078, 231-235, (1991).
Bertucco A., (1999) Precipitation and Crystallisation Techniques, Chemical Synthesis Using Supercritical Fluids, El. Jessor, P.G., 108-126.
Bleich, J. et al., (1993) Aerosol Solvent Extraction System—A New Microparticle Production Technique, Int. J. Pharm., 97, 111-117.
Blohm, D. et al., (1998) Pharmaceutical Proteins, Angew. Chem., Intl. Ed. Engl. 27, 207-225.
Dixon, D. J. et al. (1993) Polymeric Materials Formed by Precipitation with a Compressed Fluid Antisolvent, AIChE Journal, 39, 127-139.
Donsi, G. et al., Micronization by Means of Supercritical Fluids: Possibility of Application to Pharmaceutical Field, Pharm. Acta Helv., 66, 170-173. (1991).
Kikic, I. et al. (1998) Application of Supercritical Fluids to Pharmaceuticals: Controlled Drug Release Systems, Second NATO-ANSI-On Supercritical Fluids: Fundamentals and Applications, Kemer, Turkey, Jul. 1998, 291-306.
Mawson, S. et al. (1991) Stabilized Polymer Microparticles by Precipitation with a Compressed Fluid Antisolvent. 1. Poly(fluoroacrylates), Macromolecules, 30, 71-77.
Moshashaee, S. et al., (2000) Supercritical Fluid Processing of Proteins I: Lysozyme Precipitation From Organic Solution, E. J. Pharm. Sci. 11, 239-245.
Palakodaty, S., et al. (1999) Phase Behavioural Effects on Particle Formation Processes Using Supercritical Fluids, Pharm. Res., 16, 976-985.
Palakodaty, S. et al. Particle Formation using Supercritical Fluids—A Novel Approach, Proceedings, 1997 IChemE Jubilee Research Event, 501-504.
Sarup, L. et al. (2000) Investigation of Supercritical Fluid Technology to Produce Dry Particulate Formulations of Antibody Fragments, Trans IChemE, 78, part C, 101-104.
Sloan, R. (1998), in Proceeding of the 5thMeeting on Supercritical Fluids, Nice, France, Tome 1, 301-306.
Sloan, R. et al. (1999) in Proceeding of the 6thMeeting on Supercritical Fluids-Chemistry and Materials, Nottingham, UK, 169-174.
Subramaniam, B. et al., (1997) Pharmaceutical Processing with Supercritical Carbon Dioxide, J. Pharm. Sci., 86, 885-890.
Tom, J. et al., (1993) Applications of Supercritical Fluids in the Controlled Release of Drugs, Supercritical Engineering Science, American Chemical Society, 240-257.
Yeo, S. D. et al. (1993) Formation of Microparticulate Protein Powders Using a Supercritical Fluid Antisolvent, Biotechnol. Bioeng. 41, 341-346.
York, P. Strategies for Particulate Design Using Supercritical Fluid Technologies, PSTT, vol. 2, No. 1, Nov. 1999, 430-440.
Chemical Abstracts, 126:187774, Apr. 7, 1997, Columbus, Ohio.
AAPS PharmSciTech, 2002, 3(3), E18, by Martin et al. (Abstract).

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