Procedure for the preparation of dioxopenicillanic acid derivati

Details Procedure for the preparation of dioxopenicillanic acid derivati Procedure for the preparation of dioxopenicillanic acid derivati

1999-03-03

2000-12-12

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49904

Patent

active

061601128

ABSTRACT:
Procedure for the preparation of dioxopenicillanic acid derivatives and its salts pharmaceutically acceptable with general formula I, where, R is hydrogen, alkyl group containing 1 to 5 Carbon atoms or a residue of type --CH2R', where R' is hydrogen, halogen or a p-toluensulfonyl group. These are prepared by treatment of the compounds of general formula II, where R is as previously defined and X may be hydrogen or bromine, with a metallic reagent constituted by a mixture or alloy of copper and/or cobalt and/or manganese with iron and/or nickel in an aqueous/organic medium.
These compounds are useful as inhibitors of beta-lactamase. ##STR1##

REFERENCES:
CA 115:8423, abstract of Esteban-Pinilla et al, ES 2,010,485, abstract attached.
CA 121:35178, abstract of Esteban-Pinilla et al, ES 2,039,299, abstract attached.

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