Procedure for storing red cells with prolonged maintenance of ce

Details Procedure for storing red cells with prolonged maintenance of ce Procedure for storing red cells with prolonged maintenance of ce

1990-10-09

1993-10-05

Rosen, Sam

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Blood

424529, 435 2, A61K 3518

Patent

active

052503038

ABSTRACT:
This invention provides an improved method for prolonging the shelf life of transfusible red blood cells by decreasing the effective osmolality of the suspending solution and increasing the intracellular pH of the cells prior to storage thereof. This invention also provides methods whereby the intracellular pH may be increased. These methods include collecting the cells in an anticoagulant at pH 7.0 or higher and/or washing, diluting or resuspending the cells prior to storage thereof in a biologically compatible buffered solution that contains at least one non-penetrating or substantially non-penetrating anion or non-electrolyte and is substantially free of chloride ions.

REFERENCES:
patent: 4112070 (1978-09-01), Harmening
patent: 4427777 (1984-01-01), Goldstein et al.
patent: 4585735 (1986-04-01), Meryman et al.
Mueller et al.--Chem. Abstr. vol. 100 (1984) p. 207,088p.
Minakami, S. et al., In Erythrocyte Structure and Function (Brewer, C. D. Ed.) New York, Liss, pp. 149-166 (1975).
Moore et al. Post-Thaw Storage at 4.degree. C. of Previously Frozen Red Cells with Retention of 2,3 DPG. Vox Sang. 53: 15-18 (1987).
Carmen, R. A., et al., Five-week red cell storage with Preservation of 2,3 DPG. Transfusion 28: 157-161 (1988).
Meryman, H. T., Influence of Certain Neutral Solutes on Red Cell . . . Amer. J. Physiol. 225(2): 365-371 (1973).

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