Procedure for preparing salmon calcitonin

Details Procedure for preparing salmon calcitonin Procedure for preparing salmon calcitonin

1993-12-09

1996-06-18

Chan, Christina Y.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Calcitonin; related peptides

530326, 530328, 530334, 530336, 530324, 525 541, A61K 3823

Patent

active

055278817

ABSTRACT:
A procedure for the preparation of salmon calcitonin comprising the condensation of fragment 1(SEQ ID NO: 1), a docosapeptide corresponding to the carboxamide end of the salmon calcitonin sequence conveniently protected and anchored on resin, with fragment 2(SEQ ID NO:2), a decapeptide corresponding to the amino end of the salmon calcitonin sequence conveniently protected and with a disulphide bridge ready formed between the two cysteines, and the treatment of the complete peptide skeleton (fragment 6 (SEQ ID NO:6)) with an acid to liberate the totally deprotected peptide from the resin. ##STR1##

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Pepitides 1990, Proceedings of the 21st European Peptide Symposium, pp. 131-133.
"Solid phase synthesis of partially protected and free peptides containing disulphide bonds by simultaneous cysteine oxidation-release from 2-chlorotrityl resin," Barlos et al., Int'l. J. of Peptide & Protein Research, vol. 38, No. 6, 1991, pp. 562-568.
"Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids," Fields et al., Int'l. J. of Peptide & Protein Research, vol. 35, No. 3, 1990, pp. 161-214.
Guttman et al. Calcitonin 1969. Proc. 2nd Int. Symposium (21-24 Jul. 1969) pp. 74-79.
Albericio et al. J. Org. Chem. vol. 55 p. 3730 (1990).
Atherlon et al. J. Am. Chem. Soc. vol. 97, p. 6584 (1975).
Barany et al. Int. J. Pept. Prot. Res. vol. 30 p. 705. (1987).

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