Procedure for obtaining carbocalcitonin

Details Procedure for obtaining carbocalcitonin Procedure for obtaining carbocalcitonin

1994-02-03

1998-04-14

Caputa, Anthony C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Calcitonin; related peptides

530326, 530327, 525 541, A61K 3823, C07K 14585

Patent

active

057392722

ABSTRACT:
A procedure for obtaining carbocalcitonin comprising the condensation of fragment 1, a docosapeptide corresponding to the carboxamide end of the carbocalcitonin sequence, conveniently protected and anchored on resin, with fragment 2 or 3, a nonapeptide corresponding to the amino end of the salmon calcitonin sequence, with a ready-formed cycle between the Asu and Ser residua, and the treatment of the complete peptide skeleton (fragment 6 or 7) with an acid to free the totally deprotected peptide from the resin. ##STR1##

REFERENCES:
patent: 4804742 (1989-02-01), Neiss et al.
patent: 4908475 (1990-03-01), Callahan et al.
Experientia, vol.32, No. 9, 1976, pp. 1104-1106, T.Morikawa et al. "Synthesis of Eel-Calcitonia . . . Contribution of the Disulfide Bond to the Hormonal Activity".
Chemical Abstracts, vol. 114, No. 11, Mar. 18, 1991, Columbus, Ohio, US; Abstract No. 102741, Belschaw et al. "Chlorotrimehtylsilane medicated formation of omega-allyl esters of aspartic glutamic acids", p. 822, col. L; Abstract; SYNTH.COMMUN, vol. 20, No. 20, 1990, pp.3157-3160.
Barany et al. Int. J. Peptide Protein Res. vol. 30 p. 705 (1987).
Atherton et al, J. Am. Chem Soc. vol. 97 p. 6584 (1975).
Alberico et al. J. Org. Chem vol. 55 p. 3730 (1990).
Fields et al. Int. J. Peptide Protein Res vol. 35 pp. 161-214 (1990).
Sigma Catalog (1993) pp. 82-86.

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