Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1986-06-13
1990-06-19
Maples, John S.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
423 2, A61K 4902, C01G 4700
Patent
active
049352229
ABSTRACT:
A sterile pyrogen free Re.sup.196 or Re.sup.188 radiopharmaceutical is prepared by reducing radioactive perrhenate in the presence of a bone seeking ligand to form a solution including complexed Re-ligand compound together with impurities such as uncomplexed perrhenate, ReO.sub.2 and free ligand. The radiopharmaceutical is obtained by a low pressure purification method. The solution is added to a separation column, preferably an ion exchange column, and a first portion is eluted and discarded. The radiopharmaceutical is collected in a second eluted portion defined as having 25-85% of the activity of the Re on the column, less than 10% unligated perrhenate and less than 1% ReO.sub.2. This can be used as is to image and treat metastatic bone leasions. A simple kit is also disclosed.
REFERENCES:
patent: 3733388 (1973-05-01), Ziegler
patent: 4123497 (1978-10-01), Ruddock
patent: 4185078 (1980-01-01), Quatrini et al.
patent: 4387087 (1983-06-01), Deutsch et al.
patent: 4401646 (1983-08-01), Rhodes et al.
patent: 4440738 (1984-04-01), Fawzi et al.
patent: 4512967 (1985-04-01), Linder
patent: 4707544 (1987-11-01), Jones et al.
R. P. Spencer, M.D., Ph. D., "Therapy in Nuclear Medicine", 1978, pp. 257-260.
M. Eisenhut, "Iodine-131-Labeled Diphosphonates for the Palliative Treatment of Bone Metastases: 1, Organ Distribution and Kinetics of 1-131 BDP3 in Rats", The Journal of Nuclear Medicine 25:1356-1361, 1984.
Eisenhut, M., Preparation of .sup.186 Re-Perrhenate for Nuclear Medical Purposes, International Journal of Applied Radiation and Isotopes, vol. 33, pp. 99-103, (1982).
Mathieu, L. et al., Preparation of Rhenium-186 Labelled EHDP and its Possible Use in the Treatment of Osseous Neoplasms, International Journal of Applied Radiation and Isotopes, vol. 30, pp. 725-727, (1979).
Weininger, J., A. R. Ketring, E. A. Deutsch, .sup.186 Re-HEDP: A Potential Therapeutic Bone Agent, From the Chemistry Dept. of Univ. of Cincinnati, Nuklearmedizin 2 (1984).
Potsaid, M. S. et al., [32P] Diphosphonate Dose Determination In Patients with Bone Metastases from Prostatic Carcinoma, J. Nucl. Med. 19:98-104, 1978.
Deutsch Edward A.
Ketring Alan R.
Libson Karen F.
Maxon, III Harry R.
Maples John S.
University of Cincinnati
LandOfFree
Procedure for isolating and purifying radioactive ligated rheniu does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Procedure for isolating and purifying radioactive ligated rheniu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Procedure for isolating and purifying radioactive ligated rheniu will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2259319