Measuring and testing – Miscellaneous
Patent
1984-09-05
1986-06-10
Levy, Stewart J.
Measuring and testing
Miscellaneous
177 50, 422264, 422266, 73432CR, G01N 504
Patent
active
045935637
ABSTRACT:
A method and apparatus for accurately determining the rate of dissolution of solid substances with highly reproducible results is disclosed. The method and apparatus are directed to a system wherein a sample of solid, which may be powdery, is placed in a sample holder which is then immersed in a perfusion chamber. The weight of the sample is measured as a function of time as the sample dissolves. The sample holder has a variable internal volume which adjusts to the amount of sample therein so as to maintain a substantially constant liquid/solid interface area during dissolution rate measurements.
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"Comparison of the Accuracy of Different Types of Dissolution Rate Methods"; Pharmaceutisch Weekblad; 108; pp. 49-53; Dr. G. K. Bolhuis et al.; (1973).
Haapaniemi Jarkko
Laine Ensio
Labsystems Oy
Levy Stewart J.
Noland Tom
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