Procedure and device for the fusion of cells

Details Procedure and device for the fusion of cells Procedure and device for the fusion of cells

1984-06-11

1988-11-15

Warden, Robert J.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435173, 43524026, 935 93, C12N 1500, C12N 1300, C12N 500

Patent

active

047849541

ABSTRACT:
Disclosed is a process and device for fusing cells in which the cells are doped with magnetic particles and exposed to a nonhomogeneous magnetic field which permeates the fusion space in such a way that the doped cells collect close together, and then, in order to create the disruptions in the membrane structures of the adjacent cells, the cells are exposed either to the pulse of an electric field of at least the level of the breakdown voltage or to chemicals which cause the disruptions in the membrane structure such as polyethylene glycol, or to inactivated viruses which cause the disruptions in the membrane structure such as Sendai viruses.

REFERENCES:
patent: 3709791 (1973-01-01), Lichtenstein
patent: 3970518 (1976-07-01), Giaever
patent: 4441972 (1984-04-01), Pohl
patent: 4508625 (1985-04-01), Graham
patent: 4561961 (1985-12-01), Hofmann
patent: 4578167 (1986-03-01), Schoner
patent: 4578168 (1986-03-01), Hofmann
Stephenson et al., American Journal Veterinary Research, vol. 41, No. 2 (1980), pp. 234-240.
Hurrell (editer), Monoclonal Hybridoma Antibodies: Techniques and Applications, CRC Press, Boca Raton, Fla., (1982), pp. 20-24.
Biological Abstracts, vol. 70, No. 5 (1980), Abstract No. 31448, Stephenson et al.

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